Fibromyalgia and Endometriosis

Fibromyalgia and Endometriosis: Understanding the Link

Fibromyalgia and endometriosis are two long-lasting health issues that can hurt and bother people who have them. 

Fibromyalgia makes your whole body ache because it’s a problem with your nerves. Endometriosis happens when the lining of your uterus grows where it shouldn’t, which also causes pain and other troubles. 

It can be hard for doctors to figure out if you have these problems, and treating them can be tough, too. Sometimes, people have both fibromyalgia and endometriosis at the same time.

Research has shown that people with endometriosis may be more likely to have fibromyalgia than those without it. One study found that women with endometriosis were three times more likely to develop fibromyalgia than women without the condition. 

Additionally, those with endometriosis may also be more likely to have other chronic conditions, such as chronic fatigue syndrome.

How They’re Similar and Different

Fibromyalgia and endometriosis are two distinct medical conditions that share some similarities. Both conditions are associated with chronic pain, which can be debilitating and significantly impact the quality of life of those affected. However, there are also significant differences between the two conditions.


Widespread pain, fatigue, sleep disturbances, and cognitive impairment characterize fibromyalgia. The pain associated with fibromyalgia is often described as aching, burning, or stabbing and can occur in various parts of the body. 

In contrast, endometriosis primarily affects the reproductive system and can cause pelvic pain, painful periods, painful intercourse, and infertility.


Diagnosing fibromyalgia can be challenging, as there is no specific test for the condition. Doctors often rely on a combination of physical examination, medical history, and laboratory tests to rule out other conditions. 

Chronic Pain

Both fibromyalgia and endometriosis are associated with chronic pain. In fibromyalgia, the pain is widespread and can be triggered by even mild pressure. 


Inflammation is a common feature of both fibromyalgia and endometriosis. In fibromyalgia, inflammation can occur in the muscles and connective tissues, leading to pain and stiffness. In endometriosis, inflammation can occur in the reproductive organs, leading to pain and scarring.

Autoimmune Disease

Fibromyalgia is not considered an autoimmune disease, although some researchers believe that it may be associated with immune dysfunction. 


Research has shown that women with endometriosis are at a higher risk of developing fibromyalgia. Additionally, both conditions are associated with other chronic pain conditions, such as irritable bowel syndrome and chronic fatigue syndrome.

The Struggle of Getting Diagnosed

Fibromyalgia and endometriosis are two medical conditions that are often misdiagnosed or undiagnosed. Both conditions can be challenging to diagnose because their symptoms overlap with others, and no definitive tests exist.

Patients with fibromyalgia often experience chronic pain, fatigue, depression, and anxiety. These symptoms can be caused by a variety of conditions, making it challenging for doctors to diagnose fibromyalgia. 

Blood tests and imaging tests are typically standard in patients with fibromyalgia, making it even more challenging to diagnose.

Similarly, patients with endometriosis often experience chronic pelvic pain, fatigue, and depression. Endometriosis is an autoimmune disorder that affects the immune system, causing it to attack healthy tissue. 

This can make it difficult for gynecologists to diagnose endometriosis because it can mimic other gynecological conditions.

Getting diagnosed with fibromyalgia or endometriosis can be a frustrating and emotional experience for patients. Many patients are misdiagnosed or undiagnosed for years, causing them to suffer needlessly. 

Dealing with Symptoms

Pain Management

For individuals with both endometriosis and fibromyalgia, managing pain is a crucial aspect of daily life. Pain can be caused by endometrial tissue growth as well as fibromyalgia, which can cause widespread pain throughout the body. Pain relief options for these conditions can include both medication and non-medication approaches.

Medication options may include nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and opioids. However, working with a healthcare provider to determine the most appropriate medication and dosage for each individual’s unique needs is essential.

Non-medication approaches to pain management may include physical therapy, exercise, and relaxation techniques such as deep breathing and meditation. 

Mental Health

Living with chronic pain can also have a significant impact on an individual’s mental health. Fibromyalgia and endometriosis can cause mood changes, anxiety, and depression, which can further impact daily life and quality of life.

How to Treat Them

Medication and Supplements

The treatment of fibromyalgia and endometriosis typically involves a combination of medication and lifestyle changes. Medications such as antidepressants, Lyrica, and gabapentin may be prescribed to help alleviate pain and manage symptoms. 

Anti-inflammatory medications, such as ibuprofen, can also reduce inflammation. In addition to drugs, certain supplements such as Coenzyme Q10 may also be beneficial in managing symptoms.

Physical Therapy and Exercise

Physical therapy and exercise can also be effective in treating fibromyalgia and endometriosis. Physical therapy can help improve flexibility and reduce pain, while exercise can help improve overall physical and mental health. Low-impact exercises such as yoga, swimming, and walking can particularly benefit those with these conditions.

Surgery and Procedures

In some cases, surgery or other procedures may be necessary to treat fibromyalgia and endometriosis. Surgery can remove endometrial tissue or address other underlying conditions contributing to symptoms. Other procedures, such as nerve blocks or trigger point injections, may also manage pain.

Fibromyalgia and Endometriosis

Ways to Feel Better

Living with fibromyalgia and endometriosis can be challenging, but there are ways to alleviate symptoms and improve overall well-being. Here are some strategies that may help:

Prioritize Sleep

Getting enough sleep is essential for managing both fibromyalgia and endometriosis symptoms. Sleep disturbances are common in both conditions and can worsen pain and fatigue. Establishing a consistent sleep routine, avoiding caffeine and alcohol before bedtime, and creating a comfortable sleep environment can all help promote better sleep.

Address Pelvic Pain

Pelvic pain is a hallmark symptom of endometriosis and can also occur in fibromyalgia. Treatment options may include pain medications, hormonal therapies, and surgery in severe cases. Additionally, gentle exercise, heat therapy, and relaxation techniques may help alleviate pelvic pain.

Manage Irritable Bowel Syndrome (IBS)

Many people with fibromyalgia and endometriosis also experience IBS, which can cause abdominal pain, bloating, and diarrhea or constipation. Avoiding trigger foods, increasing fiber intake, and staying hydrated can all help manage IBS symptoms.

Balance Hormones

Hormonal imbalances can contribute to both fibromyalgia and endometriosis symptoms. Women with endometriosis may benefit from hormonal therapies such as birth control pills or gonadotropin-releasing hormone (GnRH) agonists. In fibromyalgia, low-dose hormone replacement therapy may help alleviate symptoms in some women.

Address Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, can also co-occur with fibromyalgia and endometriosis. Treatment options may include medications to reduce inflammation, dietary changes, and surgery in severe cases.

Alleviate Widespread Pain

Widespread pain is a hallmark symptom of fibromyalgia. Exercise, physical therapy, and relaxation techniques such as yoga or meditation may help alleviate pain and improve overall function.

Manage Sensitivity to Pain

People with fibromyalgia and endometriosis may be more sensitive to pain than others. Pain medications, physical therapy, and relaxation techniques may all help manage sensitivity to pain.

Address Menstrual Cramps

Menstrual cramps are a common symptom of endometriosis. Over-the-counter pain medications, hormonal therapies, and relaxation techniques may all help manage menstrual cramps.

Manage Painful Bladder Syndrome

Painful bladder syndrome, also known as interstitial cystitis, can co-occur with fibromyalgia and endometriosis. Treatment options may include medication to reduce bladder inflammation, dietary changes, and exercise training.


Learning about fibromyalgia and endometriosis can help people better understand their conditions and manage their symptoms. Support groups, online resources, and educational materials can all be helpful.

Frequently Asked Questions

What are the common symptoms when fibromyalgia coexists with endometriosis?

When fibromyalgia coexists with endometriosis, patients may experience overlapping symptoms such as chronic pain, fatigue, and difficulty sleeping. Patients may also experience increased sensitivity to pain, which can make it challenging to manage both conditions.

Which treatment options are available for managing both fibromyalgia and endometriosis?

There are several treatment options available for managing both fibromyalgia and endometriosis. These include pain management medications, physical therapy, and lifestyle changes such as stress reduction and regular exercise. 

How often is endometriosis incorrectly diagnosed as fibromyalgia, and what are the implications?

Endometriosis is sometimes incorrectly diagnosed as fibromyalgia due to overlapping symptoms. This can result in delayed diagnosis and treatment of endometriosis, which can lead to complications such as infertility.

Can Ehlers-Danlos syndrome complicate the diagnosis and treatment of fibromyalgia and endometriosis?

Ehlers-Danlos syndrome (EDS) is a connective tissue disorder that can complicate the diagnosis and treatment of fibromyalgia and endometriosis. Patients with EDS may experience chronic pain and other related symptoms that overlap with fibromyalgia and endometriosis.

What are the potential complications following endometriosis surgery for patients with fibromyalgia?

Patients with fibromyalgia who undergo endometriosis surgery may experience increased pain and other related symptoms following the procedure.

What gynecological issues should be monitored in patients with fibromyalgia?

Patients with fibromyalgia should be monitored for gynecological issues such as endometriosis, uterine fibroids, and pelvic inflammatory disease. These conditions can cause chronic pain and other related symptoms that may overlap with fibromyalgia. Regular gynecological exams can help detect these conditions early and improve treatment outcomes.

Fibromyalgia and Endometriosis

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